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In the human body, the gallbladder is sandwiched between the liver and the duodenum. The gallbladder is a small organ that plays a role in the metabolism of fat in the body. When food containing fat is consumed, a hormone cholecystokinin is secreted in the body. This cholecystokinin then stimulates the gallbladder to release its contents into the duodenum. Gallbladder functions in the concentration of bile produced by the liver. This bile, when released in the duodenum, emulsifies partially digested fat.
Gallbladder is found in most vertebrates but is absent in invertebrates. The removal of gallbladder does not affect survival of the organism, as no crucial functions are impaired. Gallbladder cancer is one of the rare cancers that plague human beings. Gallbladder cancer is peculiar in its geographical distribution as well as racial distribution - it is found commonly in South America, Japan, Central and Eastern Europe, South Asia, also it is commonly seen in Native American Indians and Hispanics. This could probably provide some clues about the possible risk factors and causes of gallbladder cancer, but no such trend has been yet elicit.